Gene conversion in a cytochrome P-450 gene family.
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چکیده
منابع مشابه
Gene conversion in a cytochrome P-450 gene family.
The mRNAs encoding the two major phenobarbital-inducible forms of cytochrome P-450 of rat liver, P-450b and P-450e, are remarkably similar (98% homologous) in nucleotide sequence, but the distribution of differences within them is not random. While the 5' halves (approximately equal to 1 kilobase) appear to be identical, there are 36 divergent residues in the remaining sequences of the two mRNA...
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P-450c21, a cytochrome P-450 enzyme [steroid 21-monooxygenase (steroid 21-hydroxylase), EC 1.14.99.10], mediates the 21-hydroxylation of glucocorticoid and mineralocorticoid hormones in the adrenal gland. The complete sequence of a bovine P-450c21 gene shows it is 3447 base pairs long and contains 10 exons. The intron/exon organization and encoded amino acid sequence indicate that P-450c21 repr...
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3. Warner, M., Kiihler, C., Hansson, T. & Gustafsson, J.-A. (1988) J . Neurochem. 50, 10.57-1065 4. Naslund, B., Glaumann, H., Warner, M., Gustafsson, J.-A. & Hansson. T. ( 1988) Mol. I’hnrmacol. 3 3 , 3 1-37 5. Rouet, P., Alexandrov, K., Markovits, P., Frayssinrt, C. & Dansette, P. M. ( 198 I ) Cbrcinogerresis 2 , 9 10-926 6. Rosselli, C. E., Ellinwood, W. E. & Resko, J. A. (1984) Endocrinolog...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1986
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.83.8.2300